Implant to Curb Opioid Addiction Approved by FDA, Offering New Tool to Fight Epidemic

An implantable treatment for opioid addiction was approved today by the U.S. Food and Drug Administration, adding a new option in the fight against a growing epidemic.

The implant, a match-sized rod that is inserted under the skin, releases a milder opioid drug called buprenorphine that is usually taken orally to treat addiction. Under the name Probuphine, the implant comprises four rods that release the drug at a low dose for six months.

"Anyone who's gone through addiction knows that motivation fluctuates day to day. This allows a person to decide for their future self," Dr. Keith Humphreys, a Stanford psychiatrist who also served as a senior policy advisor at the White House Office of National Drug Control Policy, told ABC News.

The implant is designed Opioid for opioid addicts who are "already stable on low-to-moderate doses" of oral buprenorphine, the FDA said in a statement. Experts like Humphreys believe this could be a game-changer for the 2.5 million Americans with an opioid addiction.



Experts also say that an implantable rod could prevent addicts from abusing the oral drug.

In January, an FDA advisory committee voted 12-to-5 to recommend the implant for FDA approval, but it was unclear how the FDA would act on that recommendation until today.

While Probuphine was found to be about as effective as the oral medication, the FDA advisory report raised the question of who would be implanting and removing the rods. Relatively few buprenorphine prescriptions are Drug written by doctors with surgical training, the report said.

"A typical psychiatrist hasn't laid their hand on a patient in 20 years," Humphreys said.



Early tests showed that even clinicians who regularly performed procedures were unable to remove the implant in some cases, according to the report.

"There have been improvements in the tools and techniques," said Behshad Sheldon, CEO of Braeburn Pharmaceuticals, which markets Probuphine with San Francisco-based Titan Pharmaceuticals.

Both the implantation and removal kits have undergone recent changes to make it easier for doctors and reduce bruising, Sheldon told ABC News.

While adverse events have been rarely reported in clinical trials, they may include infection at the injection side and potential nerve damage, according to the FDA report.

Braeburn aims to make the product widely available to patients starting June 21, said Sheldon, adding that it will cost "under $1,000 a month" but declining to provide an exact price.

But Sarah Wilson, a mother of four who was involved in the implant trials, said she has already seen some benefit.

Wilson told ABC Methadone Dose News that she became addicted to hydrocodone seven years ago after being hit by a drunk driver and developing chronic pain. She began taking oral buprenorphine to get sober and was later transitioned to the Probuphine implant.

She said she stopped worrying that her kids would get into her medication or that her local pharmacy would not have the drug in stock. She also stopped waking up in the early morning when she felt the oral drugs would wear off, she said.

"I went from existing to living," Wilson said.

ABC News' Dr. Sunjay Devarajan contributed to this report.

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Opiate Addiction Symptoms and Signs

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Opiate addiction is an insidious problem that has plagued society for centuries, but perhaps never more so than today. A two-edged sword, opiates can heal or destroy.

An opiate is any drug derived from the opium poppy plant. The main opiates are morphine, heroin, and codeine. Thebaine and papaverine are also opiates. More commonly we see opiates in their synthetic forms: oxycodone (OxyContin, Percodan), hydrocodone (Vicodin), and hydromorphone (Dilaudid). Darvon, Demerol, and Methadone are other synthetic opiates. The majority of these drugs are used medically for pain management.

Opiates are particularly effective in suppressing pain and reducing anxiety. In Opioid Treatment sufficiently high doses, they can produce a euphoric state. For this reason, they are often used as recreational drugs. Psychological and physical dependence leading to addiction is common in frequent opiate users. The body quickly adjusts to the use of opiates such that increasingly larger doses are needed to Methadone Alternative produce the same euphoric effect. Overdosing, sometimes resulting in fatal respiratory failure, occurs when addicts take more than their body can handle.

Most opiates can be swallowed, snorted, smoked, or injected. Intravenous injection is the preferred method of longtime addicts as this method produces the quickest, most intense high. It is also a method accompanied by increased risk of infectious disease.

Physically, the effects of opiates include dry mouth; muscle spasticity; slow, shallow or labored breathing; pupil dilation; stomach and intestinal spasms; constipation; low blood pressure; and diminished mental capacity, drowsiness, and disorientation. A common behavior Opiate Withdrawal of the opiate addict is the nodding in and out of consciousness.

Opiate addicts are emotionally detached. Thus, dependents of addicts are often neglected and sometimes abused. Addicts have a difficult time reporting regularly to jobs and even keeping them. Since they cannot function without the drug, looking for it, paying for it, using it, and enjoying its effects become first and foremost in their priority. Other needs are a poor second. Since funds are usually not commensurate to the need and desire, stealing and other criminal behavior are often parts of the addict's lifestyle.

Withdrawal from addiction to opiates can include hot and cold flashes, goose bumps, extreme restlessness, anxiety, muscle spasms, tremors, muscle and bone ache, insomnia, diarrhea, and vomiting.

Fortunately, there are many opiate dependency treatment programs available. Before anything else, detoxification is needed. In the opiate addiction detox center, a longtime user can begin the process of eliminating the toxins from one's body in a regulated environment where medical practitioners are available to monitor any adverse effects of withdrawal.

Some opiate addiction rehab centers administer medications such as methadone or buprenorphine to ease the pain of withdrawal. After the physical cleansing, the tough work of self-transformation begins. Opiate addiction rehabs offer counseling and behavior modification strategies and techniques to enable the recovering patient to sustain a drug-free lifestyle long after he's left Methadone High the opiate addiction rehab center. Through counseling sessions, the patient discovers the emotional and environmental factors that trigger his cravings, and he learns how to avoid these or control them. Realizing that the treatment for opiate dependency is far from over, even when the rehabilitated opiate addict returns to society, opiate addiction treatment centers connect him to support groups and family outreach programs to assist him and his family in rebuilding their lives.



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Finding the best opiate addiction detox center is a necessity in today's world. Realizing the fact the author of this article has analyzed the addiction to opiates. He knows how to find the best rehab centers. He has helped many people to find the best programs available out there.



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Solid Waste - Examiner.com

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Getting Your Personal Finance So As

Personal finance is really a tricky but critical skill in today's world. Unfortunately, it's something which is just not taught adequately and even by any means, by many people parents and schools. If you wish to learn good quality advice on the subject, keep reading this short article to find a few pointers that you may possibly stop being currently conscious of.

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With all the current information this article has to provide should already start considering strategies you need to use towards your own finance goals. Understand that this short article only contains a part of what you could find out about personal finance, so be on the lookout for additional information and apply all the things you know to complete your own finance goals.

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Suggestions To Increase Your Idea Of Personal Finance As Well As Its Importance

Do you want to make some positive financial changes? You simply need a bit education as well as do a little bit of research. Thankfully, this content below gives you many tips that can put you around the correct path.



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Recycle and reuse in order to save big dollars. Why constantly increase the environmental problems related to manufacturing and landfills? Anything that can potentially be reused should be reused. It's not shameful to accomplish this. It can be practical and admirable not merely from an environmental standpoint but also coming from a personal finance standpoint.

Stay with an affordable budget! Make time to write down the things you make and what your monthly expenditures are. This can help you decide where you should put extra money and in case you have anything leftover to pay to help make yourself some other money! No matter what form of money you make you want a budget!

Are you feeling different about the way you think of personal finances? With everything else that you just read within the above article, you ought to have the essential information to offer yourself a significantly better financial future. This will likely take some determination on your side, although the payoff of any sound financial footing is going to be definitely worth it.

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